Psoriasis Projects

From Statgen Internal Wiki
Jump to navigationJump to search

Aims/Goals for different major psoriasis projects[edit]

  • Exomearray: investigate the role of functional protein coding variation in psoriasis susceptibility
  • Target sequencing: to investigate and identify potential causal variants in known and potential psoriasis loci
  • Subphenotype (PsA, PsC, and controls) analysis: to investigate and examine the difference in genetic architecture between PsA and PsC
  • RNA-seq: to investigate the transcriptome for psoriatic skin samples and to identify potential novel transcripts that could play biologically important roles
  • Finemapping: to identify potential causal variants and to identify secondary signals within known psoriasis loci
  • 23andMe meta-analysis: to identify novel psoriasis loci through meta-analyzing different available datasets
  • eQTL study: to identify and investigate genetic variants associated with gene expression traits

Subjects[edit]

  • Cases in the case/control studies were clinically diagnosed to have psoriasis by dermatologist
  • Controls are subjects with no record of psoriasis
  • Psoriatic arthitis (PsA) cases are psoriatic patients with joint disease diagnosed by rheumatologist
  • Psoriatic cutaneous (PsC) cases are psoriatic patients have not been diagnosed to have joint disease in at least 10 years

Sequencing and genotype data[edit]

Array-based genotypes[edit]

GWAS[edit]

  • CASP GWAS (~1,400 cases and ~1,400 controls)
  • Kiel GWAS (from collaborators: ~500 cases and ~1,100 controls)
  • Genizon GWAS (from collaborators: ~800 cases and ~1,000 controls)
  • PsA GWAS (1,400 PsA cases and 1,400 normal controls)

Fine-mapping[edit]

  • Immunochip (~3,600 cases and ~6,000 controls)
  • DFU (~1,500 cases and ~1,100 controls)

Exome[edit]

  • Exomechip (~6,000 cases and ~6,000 controls)

DNA sequence data[edit]

  • U01 target sequencing (~3,000 cases and ~2,000 controls)

Array-based gene expression[edit]

  • Microarray data (~60 cases and ~60 controls)

RNA sequence data[edit]

  • RNA-seq (~100 cases and ~100 controls)

Selected references[edit]

People[edit]

Dermatology[edit]

  • JT Elder
  • Rajan Nair
  • Phil Stuart
  • Johann Gudjonsson
  • Trilokraj Tejasvi
  • William Swindell

Biostatistics Team[edit]

  • Goncalo Abecasis
  • Hyun Min Kang
  • Alex Lam C Tsoi
  • Sayantan Das
  • Matthew Zawistowski
  • William Wen
  • Nate Cohen

People worked on the Psoriasis Projects[edit]

  • Jun Ding
  • Bingshan Li
  • Yanming Li
  • Yuan Wei
  • Matthew Snyder

Point of contact at U of M[edit]

Meeting Notes[edit]

2016 Meetings

2015 Meetings

2014 Meetings

2013 Meetings

2012 Meetings

2011 Meetings

2010 Meetings

Project Pages[edit]

Retrieved from "https://statgen.sph.umich.edu/w/index.php?title=Psoriasis_Projects&oldid=20827"